Reuben Notes


Indomethacin (lndocin)

  • 25-50mg tid (25, 50, supp 50, susp 25mg/5ml)
  • (Indocin SR)-75mg PO qd/bid
  • strong NSAID


Allopurinol (zyloprim, Purinol)

  • 200-300mg PO qd/bid [100, 300]
  • inhibits xanthine oxidase(a major enzyme in uric acid synthesis)



  • po 1mg initially
  • 0.5mg q1-2h until nausea/vomiting or diarrhea occur to a maximum dose of 7-8mg,
  • IV 2mg initially, then 0.5mg q6h to a maximum dose of 4mg
  • acts by interfering with WBCs ability to phagocytize urate crystals thus reducing inflammation
  • very effective for acute attacks, but side effects often out weigh the advantages
  • can be used as a diagnostic tool for acute gout, if symptoms are relieved, it was gout


Probenecid (Benemid)

  • 250mg PO bid x7 days, then 500 bid
  • inhibits the reabsorption of uric acid in the proximal tubules


Sulfinpyrazone (Anyurane)

  • 100-200mg PO bid [100, 200]